CAS: 1331908-02-1

Valsartan-d3 is a deuterated version of valsartan, which is a pharmacological compound used for research purposes. This isotopically labeled compound is derived through the strategic substitution of hydrogen atoms with deuterium in the valsartan molecule. The incorporation of deuterium, a stable isotope of hydrogen, enhances the compound's utility in various scientific applications without altering its fundamental biological activity. The mode of action of Valsartan-d3, similar to its non-labeled counterpart, involves the selective inhibition of angiotensin II receptor type 1 (AT1). This receptor blockade results in vasodilation and a reduction in the secretion of vasopressin and aldosterone, ultimately leading to decreased blood pressure. Primarily, Valsartan-d3 is employed in pharmacokinetic studies. Its deuterated nature provides a robust tool for scientists to track and analyze the absorption, distribution, metabolism, and excretion of valsartan in biological systems using techniques such as mass spectrometry. This precise analysis aids in the understanding of drug metabolism and potential interactions, contributing significantly to the field of drug development and pharmacotherapy.