2-Chlorotetrahydrofuran is a chlorinated derivative of tetrahydrofuran (THF), characterized by the presence of a chlorine atom at the second carbon position of the tetrahydrofuran ring. This compound is a colorless liquid with a distinctive odor, and it is known for its moderate polarity and ability to dissolve a variety of organic compounds. Its molecular structure contributes to its reactivity, making it useful in various chemical syntheses, particularly in the production of pharmaceuticals and agrochemicals. The presence of the chlorine atom enhances its electrophilic character, allowing it to participate in nucleophilic substitution reactions. 2-Chlorotetrahydrofuran is also considered a potential solvent in organic reactions due to its ability to stabilize reactive intermediates. However, like many chlorinated compounds, it may pose environmental and health risks, necessitating careful handling and disposal. Its physical properties, such as boiling point and density, are influenced by the chlorine substitution, which can affect its behavior in different chemical environments.

2-Chlorotetrahydrofuran

13369-70-5: Furan, 2-chlorotetrahydro-, alpha-Chlorotetrahydrofuran

2-Chlorotetrahydrofuran is a colorless liquid with a boiling point of 33.5°C. It is soluble in carbon tetrachloride, hydrocarbons, and ethers. This compound reacts rapidly with potassium t-butoxide to form 2-chloroethyl vinyl ether (2CEVE), ethylene, and chloroform as the reaction products. The reaction can be carried out efficiently using a hydrocarbon solvent such as hexane or heptane. 2-Chlorotetrahydrofuran is an important precursor for the synthesis of pyrimidine nucleosides and other pharmaceutical compounds. It has been shown to have cytostatic activity against leukemia cells in vitro when used at high concentrations.

CAS 13369-70-5: 2-Chlorotetrahydrofuran

2-Chlorotetrahydrofuran

Ref: 3D-FC150283