CAS 1340593-59-0: Oteseconazole

Oteseconazole is an antifungal medication, which is a synthetic triazole-derived agent. It functions by inhibiting the activity of the fungal enzyme lanosterol 14α-demethylase. This inhibition disrupts the synthesis of ergosterol, a vital component of fungal cell membranes, thereby interfering with cell membrane integrity and function, ultimately leading to fungal cell death. Oteseconazole is primarily used for the treatment of recurrent vulvovaginal candidiasis (RVVC). Its selective inhibition of fungal enzymes while sparing mammalian systems enhances its safety profile. The mode of action specifically targets Candida species commonly implicated in RVVC, offering an effective treatment for patients suffering from repeated infections. Its development has broadened the scope of antifungal pharmacotherapy, particularly by providing an option that minimizes the risk of azole resistance. Further research into its applications and potential resistance mechanisms continues to be an area of active investigation in the domain of infectious disease pharmacology.

Oteseconazole

Oteseconazole (VT-1161) is an orally active anti-fungal agent.