PF-4136309, identified by its CAS number 1341224-83-6, is a small molecule that has been investigated primarily for its potential therapeutic applications, particularly in the context of cancer treatment. It functions as a selective inhibitor of certain kinases, which are enzymes that play crucial roles in various cellular processes, including cell growth and division. The compound's mechanism of action typically involves the modulation of signaling pathways that are often dysregulated in cancer cells. In terms of its physical and chemical properties, PF-4136309 is characterized by its specific molecular structure, which includes functional groups that contribute to its biological activity and solubility. The compound's efficacy and safety profile are evaluated through preclinical and clinical studies, focusing on its ability to inhibit tumor growth and its potential side effects. As with many investigational drugs, ongoing research aims to better understand its pharmacokinetics, pharmacodynamics, and overall therapeutic potential in oncology.

PF-4136309

1341224-83-6:  Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-, N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide

INCB 8761

N-[2-[(3S)-3-[[4-Hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide

PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.

CAS 1341224-83-6: PF-4136309

INCB 8761

Ref: 3D-FI104116

N-[2-[(3S)-3-[[4-Hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Ref: IN-DA00392L

PF-4136309

Ref: 54-BISN0025

PF-4136309

Ref: TM-T3430

PF-4136309

Ref: 54-BUP15176