CAS: 134419-42-4

5-Iodo-2,3-dimethoxybenzoic acid (5IMB) is a synthetic chemical that is used as a radiolabeled substrate for the synthesis of dopamine. The 5IMB is a substrate for the enzyme monoamine oxidase, which converts it to 5-hydroxyindoleacetic acid (5HIAA). The intensity of the signal emitted by 5IMB increases with the increase in concentration of dopamine. It can be used as a positron emission tomography (PET) tracer for dopamine receptors in the brain. The kinetic and uptake properties of 5IMB are different in various regions of the brain, such as striatum and caudate putamen. This difference can be measured using high-performance liquid chromatography (HPLC) and flow rate. 5IMB has been shown to have anti-oxidant properties due to its ability to scavenge peroxide radicals.