CAS: 1345839-28-2

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.

EIPA hydrochloride is a chemical compound that serves as a Na+/H+ exchange inhibitor, specifically affecting the NHE1 isoform. It is a synthetic compound with high specificity, often utilized in biochemical research to investigate the regulation of intracellular pH and cell volume. Through competitive inhibition, EIPA hydrochloride impedes the activity of the Na+/H+ exchanger, resulting in altered proton and sodium ion translocation across the cell membrane. EIPA hydrochloride is primarily employed in scientific studies exploring the physiological and pathological roles of ion transport in various cell types. Its ability to modulate ion exchange processes makes it a valuable tool for research into cardiac physiology, cancer biology, and neurological conditions where dysregulation of pH and ion balance is implicated. Researchers leverage EIPA hydrochloride to discern the mechanistic pathways of cellular responses to osmotic and metabolic stress. Its application facilitates a deeper understanding of cellular homeostasis, providing insights that may contribute to the development of therapeutic strategies targeting ion transport dysfunctions.