CAS 134612-80-9: 3-METHOXY-4-HYDROXY-5-NITROBENZYL,4'-METHYLBENZYL KETONE

3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor.

3-O-Methyl tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that is used to treat Parkinson's disease. It has been shown to increase the plasma concentrations of levodopa by about 40% in humans. This drug is also effective for the treatment of Parkinson's disease in animals, and has been shown to be safe for use in humans. 3-O-Methyl tolcapone is given orally as a tablet and it is absorbed from the gastrointestinal tract. The drug binds competitively with COMT, thereby inhibiting its activity. This inhibition leads to increased levels of levodopa and dopamine in the brain, which can improve symptoms of Parkinson's disease.

Applications Isotope labelled 3-O-Methyl Tolcapone is a metabolite of the catechol-O-Methyl transferase inhibitor Tolcapone (T535250). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Jorga, K. et al.: Br. J. Clin. Pharmacol., 48, 513 (1999); Funaki, T. et al.: J. Pharm. Pharmacol., 46, 571 (1994); Sun, J. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 877, 2557 (2009); Heizmann, P. et al.: J. Chrom. B Biomed. Sci. Appl., 730, 153 (1999);

Halogenated, sulfonated, nitrated or nitrosated derivat