CAS: 1346601-82-8

Deferiprone-d3 is a specialized form of the chelating agent Deferiprone, which is a deuterium-labeled compound. This synthetic isotope is used in various scientific studies, particularly in the field of bioinorganic and medicinal chemistry. The incorporation of deuterium, a stable hydrogen isotope, provides distinct properties that can be exploited in mass spectrometry to investigate the pharmacokinetics and metabolic pathways of chelators. The mode of action of Deferiprone-d3 involves binding free iron(III) ions, effectively forming a stable complex that facilitates the removal of excess iron from the body. This mechanism is crucial for research into disorders characterized by iron overload, such as thalassemia and hemochromatosis. By using Deferiprone-d3, researchers can study the dynamics of iron chelation and clearance without the interference of naturally occurring isotopes. Deferiprone-d3 is applied in tracer studies to elucidate the pharmacological behavior of its non-deuterated counterpart, enhancing the understanding of its distribution, absorption, metabolism, and elimination in biological systems. Its application is invaluable in refining therapeutic strategies and optimizing dosing regimens for iron overload conditions.

Applications A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro. References Kontoghiorghes, G.J.: Lancet I, 817 (1985), Kontoghiorghes, G.J., et al.: Br. J. Haematol., 62, 607 (1986), Kontoghiorghes, G.J., et al.: Biochem. Biophys. Acta, 869, 141 (1986), Kontoghiorghes, G.J., et al.: Arzneim.-Forsch., 37, 1099 (1987),