The chemical substance known as "(tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1," with the CAS number 135306-85-3, is a synthetic peptide that is a fragment of the neurokinin A (NKA) family. This peptide is characterized by its specific amino acid sequence, which includes modifications such as the incorporation of D-tryptophan at positions 6, 8, and 9, and lysine at position 10, contributing to its biological activity and stability. Neurokinins are involved in various physiological processes, including pain perception, inflammation, and neurogenic responses. The structural modifications in this peptide enhance its receptor binding affinity and may influence its pharmacological properties. Typically, such peptides are studied for their potential therapeutic applications in conditions like pain management and neurogenic inflammation. The presence of aromatic and basic amino acids in its structure suggests potential interactions with neurokinin receptors, making it a subject of interest in neuropharmacology and peptide research.

(tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1

135306-85-3: Men 10376, Neurokinin A(4-10), tyr(5)-trp(6,8,9)-lys(10)-, 5-Tyr-6,8,9-trp-10-lys-neurokinin A (4-10), Neurokinin A(4-10), tyrosyl(5)-tryptophyl(6,8,9)-lysine(10)-, L-Lysinamide, L-alpha-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-, L-alpha-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-L-lysinamide, (Tyr5,D-Trp6'8'9,Lys-NH210)-Neurokinin A (4-10), (Tyr5,D-Trp689,Lys-NH210)-Neurokinin A (4-10), H-Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2

MEN10376

MEN-10,376

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Men 10376

MEN10376 is a potent antagonist with high affinity and selectivity for the NK-2 receptor in vitro and in vivo.

CAS 135306-85-3: (tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1

MEN10376

Ref: IN-DA01E1LD

MEN-10,376

Ref: 7W-GK8847

Men 10376

Ref: TM-T16038

(Tyr⁵,D-Trp⁶·⁸·⁹,Lys-NH₂¹⁰)-Neurokinin A (4-10)

Ref: 01-4018827