CAS: 135791-48-9

6-Hydroxydopaquinone (6HDQ) is a drug product that is used as an analytical standard. It is a natural compound and an impurity of the drug product, 6-Hydroxydopamine hydrochloride. The chemical name of 6-Hydroxydopaquinone is 3,4-Dihydroxybenzoic acid methyl ester. The CAS number for this compound is 135791-48-9. Metabolism studies have been conducted on rats to determine whether 6HDQ is metabolized by cytochrome P450 enzymes or conjugated with glucuronic acid. This substance has not been shown to be a substrate for human enzymes and does not form any metabolites in vitro, making it suitable for use as an impurity standard for HPLC analysis. 6HDQ has also been synthesized from commercially available starting materials and can be custom synthesized upon request because it is not commercially available.

Applications 6-Hydroxydopaquinone is a metabolite of dopaquione, an important intermediate in melanogenesis. References Ito.S., et al.: Photochem. Photobiol., 84, 582 (2008); Tanizawa, K., et al.: Bitamin., 77, 275 (2003);

L-Topaquinone is a metabolite of dopaquione, an important intermediate in melanogenesis.