CAS 136082-41-2: 2,3-Naphthalenedimethanol,1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-6,8-dimethoxy-, (1S,2R,3R)-

(+)-5-Methoxyisolariciresinol displays significant antioxidant activities, with the IC(50) value in the range of ca. 42 to 49 microg/ml.

(+)-8-Methoxyisolariciresinol is a naturally occurring lignan, which is a class of polyphenolic compounds found predominantly in plant sources like flaxseeds, sesame seeds, and various other medicinal plants. Lignans are known for their antioxidant properties and are metabolized by intestinal microflora into enterolignans, which may exhibit various biological activities. The mode of action of (+)-8-Methoxyisolariciresinol involves its capacity to act as a radical scavenger, thereby reducing oxidative stress. Furthermore, its metabolite products can potentially modulate hormone-related pathways, interacting with estrogen receptors to varying degrees, thus impacting estrogenic and anti-estrogenic activities. This compound is examined for its applications in health-related research, primarily focusing on its anticancer, cardioprotective, and anti-inflammatory properties. In oncological studies, its influence on estrogenic activity suggests possible implications in hormone-dependent cancers, while its antioxidant capability provides a foundational basis for cardiovascular research. As a subject of phytochemical exploration, (+)-8-Methoxyisolariciresinol also sees interest in the development of functional foods and nutraceuticals aimed at disease prevention.