CAS: 1361224-53-4

AMG-3969

AMG-3969 is a piperazine derivative with a potent profile that inhibits the gluconeogenic enzymes. It has been shown to have regulatory effects on pancreatic cells and animals in vitro and in vivo. AMG-3969 is also effective at inhibiting uptake of glucose from the blood by cells in vitro, which may lead to antidiabetic effects. It is also synthesized using an asymmetric synthesis, making it a unique molecule that has not been seen before. The safety profile of AMG-3969 has been demonstrated in preclinical studies.

AMG-3969

AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).