CAS: 1364488-67-4

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate is a senolytic agent that has been shown to decrease the number of senescent cells in mice. It is a cell death inducer that selectively targets senescent cells and induces apoptosis. The drug also has anti-inflammatory properties, which may be due to its ability to inhibit the production of inflammatory cytokines such as IL-6 and IL-8 by senescent cells. Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2 carboxylate is also an inhibitor of atherosclerosis and dermatological diseases, such as acne vulgaris, ps

YH239-EE