CAS: 1365802-18-1

Imatinib Impurity E, a derivative of orally taken Imatinib, inhibits tyrosine kinases BCR/ABL, PDGFR, c-kit, and SARS/MERS-CoV.

Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity is a drug safety marker that is used to detect the presence of impurities in Imatinib. Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity is an industrial byproduct and its detection can be carried out using liquid chromatography with high sensitivity. The detection method is based on the use of a chiral column that separates the enantiomers, which are then detected using UV light at 254 nm. The elution time for this impurity is around 9 minutes. This impurity exhibits low toxicity and has been shown to have no adverse effects on human health.

Applications Des(methylpiperazinyl-N-methyl) Imatinib Dimer is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity E. It is a COVID19-related research product.