CAS 136632-28-5: trehalose-6-phosphate dipotassium

Stability Hygroscopic Applications Trehalose 6-Phosphate Potassium Salt is an intermediate in the synthesis of D-(+)-Trehalose (T718750), a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. When plants’ sugar levels are low, they reduce their investment in fatty acid synthesis. Trehalose 6-phoshate (T6P) regulates oil synthesis in plants. (Chem. and Eng. News p. 9 Oct. 1, (2018)) References Bosquillon, C. et al.: J. Cont. Rel., 99, 357 (2004); Arakawa, T. et al.: Adv. Drug Deliv. Rev., 46, 307 (2001); Singh, S.K. et al.: Pharmac. Res., 28, 873 (2011); Chem. and Eng. News p. 9 Oct. 1, (2018)

Trehalose-6-phosphate dipotassium salt is a natural sugar that is found in plants, animals, and fungi. It functions as a carbohydrate reserve and protects cells against osmotic stress. Trehalose-6-phosphate dipotassium salt can be synthesized by the enzyme trehalase from the sugar trehalose and 6-phosphate. It has been shown to protect cells from weevil infestation, which may be due to its ability to produce abiotic or biotic stress. Trehalose-6-phosphate dipotassium salt can be purified using hydrophilic interaction chromatography on an on-line system.

α,α-Trehalose 6-phosphate (Tre6P) potassium is an intrinsic 6-phosphate derivative of α,α′-trehalose and acts as an intermediary metabolite.