CAS 13670-99-0: 1-(2,6-Difluorophenyl)ethanone

2',6'-Difluoroacetophenone

2?,6?-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2',6'-Difluoroacetophenone is a pyridine compound that has been shown to have anticancer activity in vitro. The pharmacophore for this compound was elucidated by means of a dilution method and subsequent bioassay. 2',6'-Difluoroacetophenone also showed antimicrobial activity against Gram-positive and Gram-negative bacteria. It is an isomeric mixture of two compounds: 2,6-difluoroacetophenone and 4-chloro-2,6-difluoroacetophenone. These compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria. Molecular modelling studies revealed that the molecular structure of 2',6'-difluoroacetophenone can be described as a chalcone derivative with a nitrogen atom at position 3 in the phenyl ring. This molecule shows gelation properties when mixed with water or other organic solvents, which may have implications for its