CAS 137-07-5: 2-Aminothiophenol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Aminothiophenol is a chemical compound that belongs to the class of thiophenols and can be prepared by reacting sodium carbonate with hydrochloric acid. It has been shown to be an effective inhibitor of human immunoglobulin production in colorectal adenocarcinoma cells. 2-Aminothiophenol also inhibits the growth of bacteria, fungi, and some viruses. This compound binds to proteins by nucleophilic displacement of sulfur groups from cysteine residues on protein molecules, forming covalent bonds between amino groups and sulfur atoms. 2-Aminothiophenol has been used as a fluorescent derivative for the detection of disulfide bonds in proteins. The reaction mechanism is the same as that for other thiols: formation of a sulfenic acid intermediate followed by reduction to form disulfides. Analysis can be done using electrochemical impedance spectroscopy (EIS) or adsorption methods such as gas

2-Aminothiophenol was used in the synthesis of 1,5-benzothiazepines derivatives by reacting with 1,3-diphenylpropenone derivatives and using aluminosilicate solid catalysts. It was also used in the synthesis of benzothiazole2 and 3-(benzothiazol-2-yl)coumarin derivatives. The ternary complexes of copper (II) with salicylidene-2-aminothiophenol (L) and glycine, alanine, valine and histidene amino acids. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Aminothiophenol

Stability Air Sensitive Applications A multifunctional compound which shows antioxidant activity in a skin cell model of UVA-induced stress. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sies, H., et al.: Eur. J. Biochem., 215, 213 (1993), Meotti, F., et al.: Environ. Res., 94, 276 (2004),