CAS: 1370554-01-0

Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor.

Ciliobrevin D is a small molecule inhibitor, which is derived from synthetic chemical sources, specifically designed to target the function of dynein, a motor protein. It acts by inhibiting the ATPase activity of dynein, which is critical for its motor functions including cargo transport along microtubules. By impeding this action, Ciliobrevin D serves as a valuable tool in cellular and molecular biology research to probe the roles of dynein in various cellular processes. Used primarily in the study of cytoskeletal dynamics and intracellular transport mechanisms, Ciliobrevin D facilitates the investigation of dynein-related pathways. It is instrumental in elucidating the roles of dynein in processes such as mitosis, ciliary and flagellar motion, and neuronal function. Researchers employ this inhibitor to dissect the contributions of dynein-mediated transport in normal physiology and in disease states where motor protein function may be compromised, thus offering insights into potential therapeutic targets.

Applications Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein. References Firestone, A., et al.: Nature, 484, 125 (2012)

Ciliobrevin D