CAS: 137211-64-4

Prucalopride is a synthetic drug that is used in the treatment of irritable bowel syndrome. It has been shown to inhibit gastrointestinal motility and increase the number of contractions in the stomach and intestines. It is an impurity that arises during the manufacture of this drug, which can be removed through demethoxy-prucalopride synthesis. This process involves reacting prucalopride with methoxy-piperidine and carboxamide, which are catalysts for organic synthesis.

Applications N-Desmethoxypropyl Prucalopride is an impurity of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008), McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009), Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008),