CAS: 1383539-73-8

HJC0197

6-Cyclopentyl-2-((2,5-Dimethylbenzyl)Thio)-4-Oxo-1,4-Dihydropyrimidine-5-Carbonitrile

HJC0197 is a chemical compound that is an analog of the amino acid L-glutamate. It has been shown to regulate camp levels, and has shown to be effective in treating diabetic neuropathy. HJC0197 is also used as a potentiator of anticancer drugs, such as cisplatin, by binding to the cation channel and mitochondrial membrane potential. HJC0197 induces the release of vasoactive intestinal polypeptide (VIP) in hematopoietic cells which leads to increased intracellular calcium concentration. HJC0197 activates toll-like receptor 4 and 5, which are receptors found on the surface of cells that bind to endotoxins and other molecular patterns associated with bacterial infection.

HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.