CAS: 1384071-99-1

AD80 is a multi-kinase inhibitor that prevents the phosphorylation and activation of tyrosine kinases. It has been shown to inhibit the proliferation of leukemia cells in vivo. AD80 has been found to be effective against glioblastoma cells and other cancer types, such as melanoma, breast cancer, and lung cancer. AD80 inhibits protein synthesis by binding to the ATP-binding site of the enzyme kinase domain. The solubility data for AD80 shows that it is highly soluble in water and organic solvents.

AD80

AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.

1-(4-(4-Amino-1-Isopropyl-1H-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenyl)-3-(2-Fluoro-5-(Trifluoromethyl)Phenyl)Urea