(-N,O-Di-Desmethyl Tramadol, identified by its CAS number 138853-73-3, is a chemical compound that is a derivative of tramadol, a widely used analgesic. This substance is characterized by the absence of two methyl groups on the nitrogen and oxygen atoms of the tramadol structure, which influences its pharmacological properties. It is typically classified as an opioid analgesic, although its potency and efficacy may differ from that of tramadol. The compound exhibits a moderate affinity for the mu-opioid receptor and may also interact with the serotonin and norepinephrine reuptake systems, contributing to its analgesic effects. Due to its structural modifications, (-N,O-Di-Desmethyl Tramadol may have distinct metabolic pathways and potential side effects compared to its parent compound. As with many opioids, there are considerations regarding its potential for abuse and dependence, necessitating careful regulation and monitoring in clinical settings. Further research is essential to fully understand its pharmacodynamics and therapeutic applications.

(-N,O-Di-Desmethyl Tramadol

138853-73-3: cis-()-3-[1-Hydroxy-2-[(methylamino)methyl]cyclohexyl]-phenol, rel-3-[(1R,2R)-1-Hydroxy-2-[(methylamino)methyl]cyclohexyl]-phenol, 3-{1-Hydroxy-2-[(Methylamino)Methyl]Cyclohexyl}Phenol

Rac N,o-Didesmethyl tramadol is a metabolite of tramadol. Rac N,O-didesmethyl tramadol has been shown to have analgesic effects in mice and rats. It has also been shown to affect the activity of many different enzymes, including cytochrome P450s and monoamine oxidases. Rac N,o-Didesmethyl tramadol is not found in the urine of humans following oral administration but is found in wastewater treatment plant effluents. This compound has been shown to be toxic to human cells in vitro and in vivo.

rac N,o-Didesmethyl tramadol

Applications A metabolite of Tramadol.
References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),


CAS 138853-73-3: (-N,O-Di-Desmethyl Tramadol

rac N,o-Didesmethyl tramadol

Ref: 3D-NFA85373

rac N,O-Didesmethyl Tramadol

Ref: TR-D441220

Phenol, 3-[(1R,2R)-1-hydroxy-2-[(methylamino)methyl]cyclohexyl]-, rel-

Ref: IN-DA0019PQ