CAS 138977-28-3: CAPSAZEPINE
Formula:C19H21ClN2O2S
InChI:InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChI key:InChIKey=DRCMAZOSEIMCHM-UHFFFAOYSA-N
SMILES:C(NCCC1=CC=C(Cl)C=C1)(=S)N2CC=3C(=CC(O)=C(O)C3)CCC2
Synonyms:- 2H-2-Benzazepine-2-carbothioamide, N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-
- Capsazepine Synthetic Analog Of C
- N-[2-(4-Chlorophenyl)Ethyl]-1,3,4,5-Tetrahydro-7,8-Dihydroxy-2H-2-Benzazepine-2-Carbothioamide
- N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide
- N-[2-(Chlorophenyl)Ethyl]-1,3,4,5-Tetrahydro-7,8-Dihydroxy-2H-2-Benzazepine-2-Carbothioamide
- Capsazepine
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Found 11 products.
Capsazepine, 98+%
CAS:Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C19H21ClN2O2SPurity:98+%Color and Shape:Powder, Pale cream to creamMolecular weight:376.90Capsazepine
CAS:M01458 - CapsazepineFormula:C19H21ClN2O2SPurity:>99%Color and Shape:SolidMolecular weight:376.89999389648442H-2-Benzazepine-2-carbothioamide, N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-
CAS:Formula:C19H21ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:376.9002Capsazepine
CAS:Capsazepine, a TRPV1 antagonist (IC50: 562 nM), blocks capsaicin-induced heat pain.Formula:C19H21ClN2O2SPurity:98% - 99.64%Color and Shape:White To Off-White PowderMolecular weight:376.9Capsazepine
CAS:Formula:C19H21ClN2O2SPurity:≥ 98.5%Color and Shape:White crystalline powderMolecular weight:376.90Capsazepine
CAS:Controlled ProductApplications A selective vanilloid receptor antagonist (Ki=3.2uM) References Dickenson and Dray: Br. J. Pharmacol., 104, 1045 (1991), Kwak, et al.: Neuroscience, 86, 619 (1998), Szallasi and Blumberg: Pharmacol. Rev., 51, 159 (999)Formula:C19H21ClN2O2SColor and Shape:NeatMolecular weight:376.90Capsazepine
CAS:Capsazepine is a capsaicin antagonist that blocks the activation of the vanilloid receptor TRPV1. Capsazepine is used in the treatment of bowel disease and nonsteroidal anti-inflammatory drug-induced ulcers. This drug has significant cytotoxicity, as seen by its polymerase chain reaction inhibition in human colon cancer cells. It can also induce apoptosis and inhibit cancer cell growth, which may be due to its ability to block tumor necrosis factor-α (TNF-α) induced inflammation. Capsazepine has been shown to have biochemical properties similar to those of other inhibitors of TNF-α, such as myocardial infarct and toll-like receptor 4 (TLR4) signaling pathways.Formula:C19H21ClN2O2SPurity:Min. 95%Molecular weight:376.9 g/molRef: 3D-FC19673
Discontinued productCapsazepine
CAS:Formula:C19H21ClN2O2SPurity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:376.90
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