CAS 14007-09-1: 2-(2-methoxyphenoxy)propane-1,3-diol

Guaifenesin (GP) is a phenylpropanoid that is used as an expectorant and cough suppressant. Guaifenesin EP Impurity B is a by-product of the synthesis of guaifenesin, which can be removed by preparative chromatography. It has been shown to catalyze reactions with acidic substrates and has the ability to form magnesium complexes. The reaction mechanism for guaifenesin EP Impurity B is not well understood, but it has been shown that hydrotalcite and magnesium oxide can remove GP from solution. This impurity also reacts with zirconium to form zirconium oxide, which can be removed by techniques such as mesoporous silica gel chromatography.

Ether-alcohols and their halogenated, sulfonated, nitrated or nitrosated derivatives not elsewhere specified or included

Impurity Guaifenesin EP Impurity B Applications 2-(2-Methoxyphenoxy)-1,3-propanediol is a impurity of Guaifenesin (G810502. Guaifenesin Impurity D References Schieffer, G.W., et al.: J. Pharma. Sci., 72, 1856 (1984);