CAS 140158-13-0: 4'-azidothymidine 5'-triphosphate
Formula:C10H16N5O14P3
InChI:InChI=1/C10H16N5O14P3/c1-5-3-15(9(18)12-8(5)17)7-2-6(16)10(27-7,13-14-11)4-26-31(22,23)29-32(24,25)28-30(19,20)21/h3,6-7,16H,2,4H2,1H3,(H,22,23)(H,24,25)(H,12,17,18)(H2,19,20,21)/t6-,7+,10+/m0/s1
Synonyms:- Adrt 5'-triphosphate
- Adrt-TP
- Thymidine 5'-(tetrahydrogen triphosphate),4'-azido-
- [(2R,3S,5R)-2-azido-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate
- 4'-Azidothymidine 5'-triphosphate
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Found 3 products.
4'-Azidothymidine 5-triphosphate
CAS:4'-Azidothymidine 5-triphosphate (4AZTTP) is a deoxyribonucleoside that has been synthesized as an analog to thymidine. It has potent inhibitory activity against human immunodeficiency virus (HIV), and has been shown to be more effective than 2',3'-dideoxyinosine in inhibiting HIV replication. 4AZTTP inhibits the viral enzyme reverse transcriptase, which is crucial for the replication of HIV. This drug is activated by cellular enzymes and phosphorylated to 4'-azidothymidine 5'-triphosphate monophosphate, which can then bind to the viral DNA template and inhibit synthesis of RNA strands. The kinetic properties of 4AZTTP have been studied in detail using human lymphocytes as a model system for HIV infection.Formula:C10H16N5O14P3Purity:Min. 95%Molecular weight:523.18 g/mol4'-Azidothymidine 5'-triphosphate
CAS:4'-Azidothymidine 5'-triphosphate targets HIV-1 reverse transcriptase and human DNA polymerases alpha & beta.Formula:C10H16N5O14P3Color and Shape:SolidMolecular weight:523.18
