CAS 1405-97-6: Gramicidin

GRAMICIDIN CRS

SECOND INTERNATIONAL STANDARD FOR GRAMICIDIN

Gramicidin (Gramicidine) is an antimicrobial peptide. Gramicidin is effective against Gram-positive bacteria. Cost-effective and quality-assured.

Targets primarily the cell membrane of Gram-positive bacteria and shows little effect against Gram-negative bacteria. Gramicidin is typically used as a topical antimicrobial agent because it also causes hemolysis of red blood cells. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Gramicidin

Antibiotics nesoi

Gramicidin is an antibiotic, which is derived from soil bacteria of the genus Bacillus, specifically Bacillus brevis. This polypeptide antibiotic exerts its antibacterial effects by disrupting the cell membranes of susceptible bacteria. Gramicidin forms channels in the phospholipid bilayers of bacterial cell membranes, leading to uncontrolled cation fluxes, which ultimately results in cell death. This mechanism is particularly effective against Gram-positive bacteria due to their specific cell wall structure. Gramicidin is frequently utilized in topical applications, such as ointments and eye drops, due to its efficacy against a broad spectrum of Gram-positive bacterial infections. Its use is generally limited to topical formulations because systemic application can be toxic to human cells, given its non-selective mode of action on cell membranes. The compound’s unique mechanism and source make it a significant tool in combating bacterial infections, particularly in situations where topical treatment is appropriate.