CAS 14103-09-4: 1-hydroxy-2,3,4,7-tetramethoxy-9H-xanthen-9-one

1-Hydroxy-2,3,4,7-tetramethoxy-xanthone: vasodilator (EC50=6.6µM) for 5-HT-contracted arteries; inhibits osteoclast differentiation.

1-Hydroxy-2,3,4,7-tetramethoxyxanthone is a molecule that belongs to the group of flavonoids. It inhibits the activity of osteoclasts by binding to specific receptors on their surface and blocking calcium ion channels. This compound has been shown to inhibit the growth of cancer cells in vitro by inducing apoptosis and inhibiting the synthesis of DNA and protein. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone is metabolized by hepatic microsomes in rats to secoiridoids with methoxy substituents (1′,2′,3′,4′-tetrahydroxypentane). The demethylation pathway has been studied with human liver cytosolic preparations.