CAS 141433-60-5: Berberine chloride hydrate

Primarily for the treatment of gastroenteritis, dysentery and other intestinal infections and conjunctivitis, purulent otitis media. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Berberine chloride hydrate is an isoquinoline alkaloid, which is a natural compound derived from various plants, such as Berberis species, with a robust pharmacological profile. Its mode of action is primarily through the modulation of multiple biochemical pathways. Berberine activates adenosine monophosphate-activated protein kinase (AMPK), a crucial regulator of energy homeostasis, and influences lipid and glucose metabolism. It exhibits significant antimicrobial activity, disrupting microbial cell walls and inhibiting the nucleic acid synthesis of pathogens. This compound has a wide range of applications in scientific research and clinical settings. It is used to explore therapeutic strategies for metabolic disorders, including type 2 diabetes and hyperlipidemia, due to its role in improving insulin sensitivity and reducing lipid levels. Additionally, its antimicrobial properties make it a subject of interest in the study of infectious diseases, offering potential as an adjunctive treatment. Berberine chloride hydrate continues to captivate researchers due to its multifaceted biological activities and potential therapeutic applications.

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Natural Yellow 18