PF-543, with the CAS number 1415562-82-1, is a selective inhibitor of the enzyme phosphoinositide 3-kinase (PI3K), specifically targeting the PI3K gamma isoform. This compound is primarily studied for its potential therapeutic applications in various diseases, including cancer and inflammatory disorders. PF-543 exhibits a high degree of selectivity, which minimizes off-target effects, making it a valuable tool in research settings. Its mechanism of action involves the disruption of the PI3K signaling pathway, which is crucial for cell growth, proliferation, and survival. In preclinical studies, PF-543 has demonstrated efficacy in reducing tumor growth and modulating immune responses. Additionally, its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are essential for determining its suitability for further development as a therapeutic agent. Overall, PF-543 represents a significant advancement in the exploration of PI3K inhibitors and their role in treating diseases associated with dysregulated PI3K signaling.

PF-543

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PF 543

PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.

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CAS 1415562-82-1: PF-543

PF 543

Ref: IN-DA009BPF

PF-543

Ref: 54-BUP08535

PF-543

Ref: TM-T6085

Sphingosine Kinase 1 Inhibitor II, PF-543

Ref: 3D-QGC56282