CAS: 1415562-83-2

PF 543 citrate is a research tool that can act as an activator or ligand of receptors. It has been shown to bind with high affinity to the M2 muscarinic receptor and inhibit the binding of acetylcholine. PF 543 citrate binds to the extracellular domain of the receptor, blocking acetylcholine from activating the M2 muscarinic receptor, thereby inhibiting the ion channel opening. This compound also binds to other types of ion channels, such as nicotinic acetylcholine receptors and potassium channels. PF 543 citrate is a potent inhibitor of protein interactions in cell biology and pharmacology.

PF-543 Citrate is an SPHK1 inhibitor and also an inhibitor of S1P formation, exhibiting anticancer, antifibrotic, and anti-inflammatory activities.