CAS 1421373-99-0: N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide

Applications AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC). References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);

AZ7550

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide is a selective kinase inhibitor, which is synthesized through advanced chemical processes targeting specific molecular structures. This compound operates by selectively inhibiting certain protein kinases involved in cellular signaling pathways, effectively disrupting proliferative signaling in cancer cells. The primary use of this compound is in oncology research, where it aids in the exploration of targeted cancer therapies. By inhibiting aberrant kinase activity, it plays a crucial role in understanding tumor growth mechanisms and the development of novel therapeutics. Its specificity enables researchers to dissect cellular pathways with precision, making it an invaluable tool in the study of cancer progression and treatment strategies.