CAS: 1421448-26-1

GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.

GN44028

GN 44028 is a synthetic small molecule, which is an ATP-competitive inhibitor developed through advanced medicinal chemistry techniques. It specifically targets serine/threonine kinases, a class of enzymes pivotal in cellular signaling and regulation. The inhibitor achieves its effects by binding to the ATP-binding site of these kinases, thereby blocking substrate phosphorylation and downstream signal transduction pathways. This product is extensively used in biochemical assays and cellular biology studies to investigate kinase-mediated signaling pathways. By inhibiting specific kinase activity, GN 44028 helps elucidate the roles of these enzymes in processes such as cell growth, apoptosis, and differentiation. Its potent and selective action makes it an essential tool in cancer research, where dysregulation of kinase activity often contributes to tumorigenesis. Additionally, it serves as a valuable compound for drug discovery, aiding in the validation of potential therapeutic targets and providing insights into kinase inhibitor design strategies. Researchers employ GN 44028 to deepen understanding of molecular dynamics within cellular environments, advancing both biological sciences and therapeutic development.