CAS: 1422252-46-7

BIX HCl is a sodium-hydrogen exchange type 1 inhibitor.

BIX is an NHE1 inhibitor, which is a small molecule compound derived from chemical synthesis. It specifically targets the Na+/H+ exchanger 1 (NHE1), a protein involved in the regulation of intracellular pH. The mode of action of BIX involves the inhibition of NHE1, leading to altered proton exchange across the plasma membrane. This action affects the cellular pH homeostasis and ion balance, which can influence various cellular processes such as cell proliferation, apoptosis, and migration. The applications of BIX are primarily in the field of biomedical research, where it is utilized to study the physiological and pathological roles of NHE1 in different cell types and tissues. It is particularly significant in cancer research, where NHE1 activity is often upregulated, contributing to the malignant phenotype. By understanding the effects of BIX, researchers can explore the potential therapeutic implications of targeting NHE1 in tumor progression, cardiovascular diseases, and other conditions influenced by dysregulated pH dynamics.