CAS 142341-05-7: [[[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl 2,2-dimethylpropanoate

Applications The monoester metabolite of the adefovir prodrug Adefovir Dipivoxil (A280465). References Shaw, J.-P. et al.: Drug Metab. Dispos., 25, 362 (1997); Annaert, P. et al.: Pharmac. res., 15, 1168 (1998); Annaert, P. et al.: J. Pharmac. Sci., 89, 1054 (2000);

Adefovir Monopivoxil is a prodrug that is converted to adefovir, an antiviral drug, in the body. The preparation process of Adefovir Monopivoxil is based on the basic research of adefovir and its efficiency was proved by reproducible experiments. It has been shown that Adefovir Monopivoxil can inhibit the growth of viruses by inhibiting the synthesis of virus-specific single-stranded DNA or RNA in infected cells. It also has low bioavailability, which may be due to alkylene groups that cause slow absorption from the gastrointestinal tract. Adefovir Monopivoxil is orally active and can be used for treatment of chronic hepatitis B virus infection.