CAS: 1423715-09-6

Applications SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent. References Sorna, V. et al.: J. Med. Chem., 56, 9496 (2013); Fiskus, W. et al.: Leukemia, 11, 2155 (2014);

SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).

Lysine-specific demethylase 1 ( LSD1) antagonist

SP2509