CAS: 1426397-23-0

Cefsulodin Sodium Salt Hydrate is an antibiotic compound, which is derived from synthetic chemical processes, specifically designed as a third-generation cephalosporin. It exhibits a mode of action by inhibiting bacterial cell wall synthesis, effectively targeting certain Gram-negative bacteria, particularly Pseudomonas aeruginosa, through the binding of penicillin-binding proteins. This binding disrupts the transpeptidation process essential for peptidoglycan cross-linking, compromising bacterial cell wall integrity and leading to cell lysis. The uses and applications of Cefsulodin Sodium Salt Hydrate are primarily in microbiological research and diagnostic media formulations where selective suppression of bacteria is required. It is particularly effective in differentiating Pseudomonas species within mixed bacterial populations found in clinical and environmental samples. In laboratory settings, this compound facilitates the isolation and identification of target microorganisms by ensuring the inhibition of competing flora. Its specificity and efficacy make it an invaluable tool in the study of bacterial growth dynamics and antibiotic resistance mechanisms.

Cefsulodin is most commonly used in CIN agar to select for Yersinia microorganisms. The compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-resistant mutants of Pseudomonas aeruginosa PAO4089 growth displayed that Cefsulodin sodium salt hydrate may compete with PBP3 in addition to PBP1A and PBP1B. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.