CAS: 142796-21-2

Isosilybin A is a flavonolignan, which is a bioactive compound found in the seeds of the milk thistle plant, Silybum marianum. Derived from a natural source, it is known for its potent antioxidant properties and is part of the complex mixture of compounds known as silymarin. Its mode of action involves inhibiting the proliferation of cancer cells through modulation of cell cycle regulators and induction of apoptosis. Isosilybin A also exhibits anti-inflammatory activity by inhibiting key cytokines. In terms of uses and applications, Isosilybin A is primarily researched for its chemopreventive and hepatoprotective activities. It has shown promise in studies focusing on liver diseases, such as hepatocellular carcinoma, and in prostate cancer models. Additionally, it is studied for its potential in treating skin disorders due to its ability to protect dermal cells from oxidative stress. As a research compound, it continues to be a subject of interest for its therapeutic prospects in oncology and hepatology.

Oxygen-heterocyclic compound

Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (