4-N-benzoylgemcitabine is a synthetic nucleoside analog derived from gemcitabine, which is primarily used in cancer therapy. This compound features a benzoyl group attached to the nitrogen atom of the gemcitabine structure, enhancing its pharmacological properties. It exhibits characteristics typical of nucleoside analogs, including the ability to interfere with DNA synthesis and repair mechanisms, making it a potential candidate for antitumor activity. The compound is generally characterized by its solubility in organic solvents and limited solubility in water, which can influence its bioavailability and therapeutic efficacy. Its mechanism of action involves incorporation into DNA, leading to chain termination during replication. Additionally, 4-N-benzoylgemcitabine may exhibit varying degrees of cytotoxicity against different cancer cell lines, depending on factors such as concentration and exposure time. As with many chemotherapeutic agents, its development and application are subject to ongoing research to optimize its effectiveness and minimize side effects.

4-N-benzoylgemcitabine

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N6-Benzoyl-2'-deoxy-2',2'-diflurocytidine is a Nucleoside Derivative - Fluoro-modified nucleoside.

N6-Benzoyl-2'-deoxy-2',2'-diflurocytidine

N-Benzoyl-2'-deoxy-2',2'-difluorocytidine is a novel nucleoside analog with potent antiviral and anticancer activity. It is an activator of the enzyme ribonucleotide reductase and inhibits DNA synthesis. N-Benzoyl-2'-deoxy-2',2'-difluorocytidine has been shown to be an effective inhibitor of human immunodeficiency virus type 1 (HIV-1) replication in vitro, as well as the growth of human tumor cells in vivo.

CAS 142816-70-4: 4-N-benzoylgemcitabine

N6-Benzoyl-2'-deoxy-2',2'-diflurocytidine

Ref: TM-TNU1297

N-Benzoyl-2'-deoxy-2',2'-difluorocytidine

Ref: 3D-NB158397

Gemcitabine Impurity 31

Ref: 4Z-G-2649