CAS: 1428629-70-2

Propargyl-PEG4-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Propargyl-PEG4-NHS ester is a PEG product that is commonly used in bioconjugation and pegylation applications. It is a heterobifunctional PEG with an alkyne group on one end and an N-hydroxysuccinimide (NHS) ester on the other end. This PEG linker provides a versatile tool for attaching molecules to proteins, peptides, or other biomolecules through bioorthogonal click chemistry reactions. The propargyl PEG can be easily reacted with azide-functionalized molecules using copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. The NHS ester group allows for efficient coupling to primary amines on biomolecules, creating stable amide bonds. With its high purity and excellent water solubility, Propargyl-PEG4-NHS ester is an ideal