CAS 142885-92-5: Omeprazole Sulfide N-Oxide

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole N-oxide is a sulfoxide that belongs to the family of medicines called proton pump inhibitors. It is a stereoselective proton pump inhibitor due to its cyclic nature and has been used as a pharmaceutical preparation for the treatment of gastroesophageal reflux disease. 5-Methoxy-2-[(4-methoxy-3,5-dimethylpyridinium) methylthio]-1H benzimidazole N oxide has been shown to be an enantiomerically pure salt form with magnesium chloride.

Applications 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole N-Oxide is a metabolite of Omeprazole (O635000), an proton inhibitor used as an antiulcerative agent. References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)