CAS: 1429882-07-4

MRX-2843

MRX-2843 is a small molecule that inhibits the tyrosine kinase activity of Flt3. Flt3 is a receptor tyrosine kinase which plays an important role in T-cell leukemia, autoimmune diseases, and inflammation. MRX-2843 also has anti-infective properties and can be used to treat bacterial infections such as tuberculosis. In preclinical studies MRX-2843 was shown to inhibit the growth of cancer cells in cell culture and xenograft models. It also showed efficacy against wild-type mice with leukemia when administered orally or intravenously, but not when given topically.

Applications MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3. References Minson, K. A. et al.: JCI Insight. 2016 Mar;1(3):e85630.;

MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).