CAS 142992-99-2: 1-(3-nitrophenyl)guanidine nitrate

Applications Used for the preparation of N-thiazolpyrimidinyl-N-phenylamines as specific cyclin-dependent kinase inhibitors useful as antitumor agents. References Buchdunger, E., et al.: J. Pharmacol. Exp. Ther., 295, 139 (2000), Szakacs, Z., et al.: J. Med. Chem., 48, 249 (2005), Pietras, K., et al.: Cancer Cell., 3, 439 (2003), Mahboobi, S., et al.: Eur. J. Med. Chem., 43, 1444 (2008),

3-Nitrophenylguanidine nitrate is a drug that targets the enzyme kinases, which are involved in the regulation of cell growth and division. It has been shown to inhibit the activity of stromal tumor cells, as well as chronic myeloid leukemia cells. 3-Nitrophenylguanidine nitrate inhibits protein synthesis by inhibiting demethylation and efflux, which enables imatinib to bind to the target site. This drug also has a rapid onset of action and can be used for monitoring chronic myeloid leukemia patients without the need for positron emission tomography (PET) scanning.