Interleukin 1 receptor antagonist (IL-1ra) is a naturally occurring protein that plays a crucial role in the regulation of inflammatory responses. The specific isoform mentioned, human isoform x reduced, refers to a variant of this protein that is involved in inhibiting the activity of interleukin-1 (IL-1), a pro-inflammatory cytokine. By binding to IL-1 receptors without activating them, IL-1ra effectively blocks the inflammatory signaling pathways initiated by IL-1, thereby modulating immune responses. This characteristic makes it significant in the context of various inflammatory diseases, including rheumatoid arthritis and other autoimmune conditions. The CAS number 143090-92-0 identifies this specific form of IL-1ra, which is synthesized as a peptide and can be produced through recombinant DNA technology. Its therapeutic potential is being explored in clinical settings, particularly for conditions characterized by excessive inflammation. Overall, IL-1ra serves as a critical component in the balance of immune system activity, highlighting its importance in both health and disease.

Interleukin 1 receptor antagonist, (human isoform x reduced), N2-L-methionyl-

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Anakinra is a recombinant human IL-1 receptor antagonist protein that binds to IL-1 receptors and blocks the binding of IL-1, preventing the formation of IL-1 complexes with its receptors and thereby inhibiting inflammation. It is used for the treatment of rheumatoid arthritis and other autoimmune diseases. Anakinra has been shown to inhibit ion channels and has high purity.

Anakinra

Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. It is the first biological agent to block the pro-inflammatory effects.

CAS 143090-92-0: Interleukin 1 receptor antagonist, (human isoform x reduced), N2-L-methionyl-

Anakinra

Ref: 3D-TFA09092

Anakinra

Ref: TM-T10317