CAS 14340-01-3: Gestadienol

Gestadienol is a synthetic, reconstituted drug that is used to treat congestive heart failure. Gestadienol is produced by reacting hydrochloric acid with isopropyl palmitate and diluent. The reaction yield of this process can be increased by implanting the drug into animal tissue for a period of time before extraction. Gestadienol binds to glucuronidated compounds in the blood, which may be due to its chemical similarity to estradiol. This binding prevents the glucuronidated compound from being excreted in urine and increases their concentration in the bloodstream. Gestadienol has been shown to increase postnatal development in rats, which may be due to its ability to bind progesterone receptors on cells and inhibit progesterone-mediated effects.

Applications Gestadienol is a progesterone (P755900) used in the study of human membrane progesterone receptor alpha (hu-mPRα) and nuclear progesterone receptor (nPR). References Kelder, J., et al.: Steroids, 75, 314 (2010)