CAS 143664-11-3: Elacridar
Formula:C34H33N3O5
InChI:InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
InChI key:InChIKey=OSFCMRGOZNQUSW-UHFFFAOYSA-N
SMILES:C(NC1=CC=C(CCN2CC=3C(CC2)=CC(OC)=C(OC)C3)C=C1)(=O)C4=C5C(C(=O)C=6C(N5)=C(OC)C=CC6)=CC=C4
Synonyms:- 4-acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-
- Gf 120918
- Gf 129018
- Gg 918
- Gw 0918
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- N-{4-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl}-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- Elacridar
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Found 11 products.
Elacridar
CAS:ElacridarFormula:C34H33N3O5Purity:By hplc: 100% (Typical Value in Batch COA)Color and Shape: solidMolecular weight:563.64g/molElacridar
CAS:Controlled ProductApplications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport. References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007),Formula:C34H33N3O5Color and Shape:NeatMolecular weight:563.64Elacridar
CAS:Formula:C34H33N3O5Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Green powder to crystalMolecular weight:563.65Elacridar
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C34H33N3O5Color and Shape:Almost white to yellow, PowderMolecular weight:563.65Elacridar
CAS:Inhibitor of ABC transporters; oral bioenhancer for anti-cancer therapyFormula:C34H33N3O5Purity:Min. 98 Area-%Color and Shape:Yellow PowderMolecular weight:563.64 g/molElacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formula:C34H33N3O5Purity:100% - 99.62%Color and Shape:SolidMolecular weight:563.64Ref: TM-T2657
5mg42.00€10mg63.00€25mg107.00€50mg188.00€100mg283.00€200mg472.00€500mg753.00€1mL*10mM (DMSO)57.00€Elacridar - Bio-X ™
CAS:Elacridar is an inhibitor of ATP-dependent transport, which is mediated by P-glycoprotein (P-gp). Functioning as an oral bioenhancer, Elacridar addresses multiple drug resistance in tumors, a common challenge in cancer treatment often linked to changes in the expression of protein inhibitors. Inhibition of P-gp by Elacridar is a key mechanism behind its effectiveness. P-glycoprotein, a well-characterized human ABC transporter of the MDR/TAP subfamily, acts as an ATP-dependent efflux pump with broad substrate specificity. Its increased expression in the intestines can hinder drug absorption, leading to reduced bioavailability and inadequate therapeutic plasma concentrations. Elacridar addresses this challenge by inhibiting P-gp, thereby increasing the bioavailability of coadministered drugs. Overall, Elacridar emerges as a promising option for the treatment of solid tumors, offering a strategic approach to overcoming multidrug resistance in cancer therapy. Elacridar is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C34H33N3O5Purity:Min. 95%Color and Shape:PowderMolecular weight:563.64 g/molRef: IN-DA00AOQ8
1gTo inquire5gTo inquire10gTo inquire1mg26.00€25gTo inquire5mg52.00€10mg68.00€25mg129.00€50mg173.00€100mg195.00€250mg347.00€Elacridar
CAS:Formula:C34H33N3O5Purity:≥ 98.0%Color and Shape:Off-white to yellow powderMolecular weight:563.64
