CAS 143748-18-9: Pituitary Adenylate Cyclase Activating Polypeptide (6-38) amide (human, ovine, rat)

PACAP is a peptide that belongs to the class of activators. It is used as a research tool for its ability to activate ion channels in mammalian cells. PACAP interacts with receptors and can be found in both the central nervous system and peripheral tissues. The receptor for PACAP, known as the PAC1 receptor, is coupled to G-proteins and regulates adenylate cyclase activity. PACAP has been shown to inhibit cell proliferation and promote apoptosis in various types of cancer cells. PACAP also stimulates the release of oxytocin from neurohypophysis cells, which may lead to its use as a treatment for autism spectrum disorders or depression.

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The PACAP selective antagonist PACAP (6-38) is a potent and selective inhibitor of PACAP-27-stimulated pituitary adenylate cyclase with a Ki values of 150 nM.

Please enquire for more information about PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

PACAP (6-38) in humans, sheep, rats: a strong inhibitor of PACAP 38, outperforms PACAP (6-27) in blocking PACAP-27-induced adenylate cyclase.