CAS 144409-99-4: amyloid B-protein

Inactive control

Amyloid-β (Aβ) is a globular protein of about 40 amino acids that is the major constituent of amyloid plaques. Aβ is derived from sequential proteolytic processing of amyloid precursor protein (APP) by enzymes called β-secretase and γ-secretase. The Aβ1-40 fragment has been implicated in Alzheimer's disease, and its production can be inhibited by antibodies. The fragment consists of 40 amino acids and contains a central region that shares sequence similarity with the immunoglobulin fold, flanked on either side by β-strands. The N terminus is hydrophobic while the C terminus is hydrophilic. It has been shown to form ion channels in lipid bilayers, which can be blocked by various ligands such as antibodies or peptides. CAS No.: 144409-99-4

Trifluoroacetate salt

Hydrochloride salt

Amyloid Beta-Protein (40-1) is a peptide that is found in the brain, and is thought to be involved in Alzheimer’s disease. Amyloid Beta-Protein (40-1) has been shown to inhibit protein interactions and activator functions, as well as act as a ligand for receptors. This protein can be used as a research tool for studying ion channels and antibodies. It also has high purity and can be used for life science experiments.

Reverse sequence of Aβ 1-40. Inactive control for Aβ40.