CAS 144432-85-9: 3-Chloro-4-fluorophenylboronic acid

3-Chloro-4-fluorobenzeneboronic acid is used as a reactant for Rh-catalyzed asymmetric addition reactions, palladium-catalyzed oxidative cross-coupling reaction and Suzuki-Miyaura coupling. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3-Chloro-4-fluorobenzeneboronic acid

3-Chloro-4-fluorophenyl)boronic acid (3CFPBA) is a boronic acid that is used in asymmetric synthesis. It has high lipophilicity and can be taken up by the brain. 3CFPBA has been shown to bind to naphthalene, which is a natural compound, with a binding constant of 2.6 x 10^10 M^-1. This molecule has been found to inhibit the production of beta amyloid peptides in Alzheimer's disease . 3CFPBA also binds to other heterocycles such as furan and pyrrole, which are found in molecules such as phenol and benzene respectively.