CAS 1445-45-0: 1,1,1-Trimethoxyethane

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Trimethyl Orthoacetate is used as a reagent in the synthesis of Pseudomonic Acid D Sodium (P839520); an antibiotic isolated from Pseudomonas fluorescens. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Banks, R.M., et al.: J. Antibiot., 41, 609 (1988); Sridhar, Y., et al.: Org. Biomol. Chem., 12, 2950 (2014)

Trimethyl orthoacetate is a reactive chemical compound that reacts with alkanoic acids to produce esters. It is a colorless liquid at room temperature and has a pleasant odor. Trimethyl orthoacetate can be used in the synthesis of esters, which are important intermediates in the development of pharmaceuticals and agrochemicals. The reaction mechanism of trimethyl orthoacetate has been studied by means of matrix effect and kinetic energy analysis, showing that it is an exothermic reaction. This chemical reacts with water to form hydrogen gas and acetone, which can be dangerous if it occurs on an industrial scale. Trimethyl orthoacetate also acts as a glp-1r agonist, which regulates blood sugar levels, and as such might have potential use in the treatment of type 2 diabetes mellitus.

Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.