CAS: 1445846-30-9

Gpr84 antagonist 8 is a small molecule inhibitor, which is synthetically derived, with a specific mode of action targeting the G protein-coupled receptor 84 (GPR84). This antagonist functions by inhibiting the receptor's signaling pathways, which are primarily associated with the modulation of inflammatory and metabolic processes. GPR84 is activated by medium-chain fatty acids and plays a significant role in immune cell regulation, particularly in monocytes and macrophages. The application of Gpr84 antagonist 8 is prominent in research settings aimed at understanding the pathophysiology of inflammatory diseases and metabolic disorders. By blocking GPR84, this antagonist can down-regulate pro-inflammatory cytokine production, offering potential insights into therapeutic strategies for conditions such as inflammatory bowel disease, diabetes, and other metabolic dysfunctions. Furthermore, Gpr84 antagonist 8 is instrumental in elucidating the receptor's role in various cellular and physiological contexts, making it a valuable tool for scientists exploring the intricate web of immune system responses.

GPR84 antagonist 8 is a selective GPR84 antagonist.